Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 335
  • Home
  • Print this page
  • Email this page


 
 Table of Contents  
CASE REPORT
Year : 2017  |  Volume : 3  |  Issue : 1  |  Page : 36-38

A rare case of primary benign schwannoma of the pleura


Department of Radiology, St. John's Medical College, Bengaluru, Karnataka, India

Date of Web Publication19-Jun-2017

Correspondence Address:
Reddy Ravikanth
St. John's Medical College, Bengaluru - 560 034, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/digm.digm_31_16

Rights and Permissions
  Abstract 

Schwannoma, also called neurilemmoma, is a benign peripheral nerve sheath tumor. Most common locations are flexor surfaces of the extremities, neck, mediastinum, retroperitoneum, posterior spinal roots, and cerebellopontine angle. Pleural schwannomas are extremely rare neoplasms of the thoracic cavity. To the best of our knowledge, till date, <20cases have been reported. Herein, we report a case of primary benign pleural schwannoma in an elderly 60-year-old female in whom the pleural mass was discovered incidentally on computed tomography chest. The patient was subjected to left posterolateral thoracotomy; pleural mass was resected which showed histopathological and immunohistochemical features of schwannoma.

Keywords: Histopathology, imaging, pleura, schwannoma, thoracic cavity


How to cite this article:
Ravikanth R. A rare case of primary benign schwannoma of the pleura. Digit Med 2017;3:36-8

How to cite this URL:
Ravikanth R. A rare case of primary benign schwannoma of the pleura. Digit Med [serial online] 2017 [cited 2019 Jun 27];3:36-8. Available from: http://www.digitmedicine.com/text.asp?2017/3/1/36/208447


  Introduction Top


Schwannoma is an encapsulated benign peripheral nerve sheath tumor which is almost always solitary. Common locations are the flexor surfaces of the extremities, neck, mediastinum, retroperitoneum, posterior spinal roots, and cerebellopontine angle.[1] Pleural schwannomas are rare and arise from the autonomic nerve fiber sheaths in the pleura. They are generally benign, asymptomatic, slow-growing lesions, and occur more commonly in adults with a male predominance. Histopathological differential diagnosis includes neurofibroma and other benign spindle cell tumors such as leiomyoma, leiomyosarcoma, and calcifying aponeurotic fibroma which may also show palisading of the nuclei.[2] Histopathological variants of this lesion are ancient schwannoma, benign myxoid schwannoma, benign epithelioid schwannoma, benign glandular schwannoma, and psammomatous melanotic schwannoma.[2]


  Case Report Top


A 60-year-old woman presented with respiratory symptoms due to acute exacerbation of asthma. The patient is a known seasonal asthmatic for 10years. Physical examination revealed bilateral wheeze. All routine laboratory investigations were within normal limits. Computed tomography(CT) scan chest showed evidence of well-defined, cystic mass with partial peripheral enhancement measuring 6 cm × 4 cm involving the left side of posterior mediastinum. No pleural effusion/thickening observed [Figure 1]. A radiological diagnosis of “posterior mediastinal cystic mass-neurofibroma” was considered. The patient was posted for surgery and a left posterolateral thoracotomy was done. Amass was seen arising posteriorly from the pleura, measuring 7cm×5cm, which was predominantly cystic. R0 excision of pleural mass was done corresponding to resection for cure or complete remission and specimen sent for histopathological examination. Gross examination of the specimen revealed gray-white solid and membranous soft tissue bits partly cystic, showing mucoid and hemorrhagic areas. Microscopic sections studied from the specimen revealed a well-encapsulated mass showing benign spindle cells with alternating hypercellular Antoni A areas with nuclear palisading with Verocay bodies formation and hypocellular Antoni B areas showing myxoid changes and thick-walled blood vessels with perivascular hyalinization. No mitosis or necrosis was noted. Aprovisional diagnosis of schwannoma was considered. Immunohistochemistry(IHC) stain S-100 performed showed diffuse and strong positivity of tumor cells. Based on histopathology and IHC, a final diagnosis of primary pleural benign peripheral nerve sheath tumor consistent with schwannoma was made. The patient had an uneventful postoperative recovery with no adjuvant therapy. Postoperative investigations included a contrast-enhanced CT(CECT) thorax, which showed no residual tumor/collections. Six months later, the patient was completely asymptomatic, and follow-up of CECT thorax showed no evidence of tumor recurrence.
Figure 1: Axial contrast-enhanced computed tomography image of the chest demonstrating a left-sided posterior mediastinal cystic mass lesion (star) showing peripheral enhancement (arrow)

Click here to view



  Discussion Top


Primary pleural schwannomas are exceedingly rare neoplasms.[3] They account for 1%–2% of all thoracic tumors.[4] Although it can occur at any age, pleural schwannomas commonly affect adults between their third and sixth decades. In addition, males are more commonly affected than females.[5] Majority of pleural schwannoma are benign though malignancy has been reported in some cases.[6] Schwannomas arise from specialized myelin-producing cells-Schwann cells, of either the sympathetic or parasympathetic autonomic nerve fiber sheaths.[7] Schwannomas arising in the pleural surface of the lung generally grow slowly; hence, they do not usually produce symptoms. The majority of patients with pleural schwannomas are often asymptomatic or may present with nonspecific and vague symptoms. Therefore, the vast majority of pleural schwannomas are discovered incidentally during investigations for other complaints.

Although they are rarely encountered, malignant pleural schwannomas have been reported in literature.[8] Malignant lesions have been described in patients with neurofibromatosis Type1 and patients with positive history of previous radiation therapy.[9] In addition, malignant pleural schwannomas are likely to produce symptoms due to their large size compared to benign lesions. Large tumors have the potential to produce pain and neurological symptoms due to their mass occupying effect and compression on adjacent structures.[10] Diagnosing pleural schwannomas is often challenging. Definitive diagnosis cannot be reached even with advanced imaging modalities and laboratory investigations.

Radiological images aid in raising the suspicion about the nature of the lesion and narrowing the differential diagnosis. Pleural schwannomas should be included in the differential diagnosis of solitary, solid, well-demarcated pleural lesions, which include, but are not restricted to, pleural lipomas, pleural metastasis, mesotheliomas, and solitary fibrous tumors. Moreover, laboratory tests usually lie within normal limits. Therefore, definitive diagnosis can only be established through histopathological examination and IHC staining of the neoplasm, which requires a section of the tumor. CT scan remains the diagnostic imaging modality of choice for these neoplasms. CT scan can outline the size, number, and exact location of the lesions. CT scan can also demonstrate cystic and/or solid components of the tumor. Malignant pleural schwannomas have similar features on CT scan; however, they are usually associated with the presence of pleural nodules, pleural effusions, and metastatic pulmonary nodules.[11] Microscopically, Antoni A and Antoni B areas are revealed in the majority of pleural schwannoma cases. Antoni A represents areas of hypercellularity with Verocay bodies. Antoni B areas of myxoid hypocellularity exhibit degenerating changes (i.e., cyst formation, hemorrhage, calcification, xanthomatous infiltration, and hyalinization).[12] Immunohistochemically, pleural schwannomas typically stain diffusely and strongly positive for S-100 protein.


  Conclusion Top


Pleural schwannomas are extremely rare neoplasms of the thoracic cavity. Imaging and histopathological examinations are necessary to diagnose pleural schwannomas. The standard care of the management of pleural schwannomas is primarily surgical resection thoracoscopically or complete pleural resection of the tumor whenever technically possible with frequent continuous follow-up.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
GabrielR, RaoA. Digital neurilemmoma: Acase report. Bahrain Med Bull 2002;24:76-7.  Back to cited text no. 1
    
2.
Rosai J. Rosai and Ackerman's Surgical Pathology, Vol. 2, 9th ed. China: Mosby, 2004. p. 2264-6.  Back to cited text no. 2
    
3.
McClenathanJH, BloomRJ. Peripheral tumors of the intercostal nerves. Ann Thorac Surg 2004;78:713-4.  Back to cited text no. 3
[PUBMED]    
4.
AthanassiadiK, KalavrouziotisG, RondogianniD, LoutsidisA, HatzimichalisA, BellenisI. Primary chest wall tumors: Early and long-term results of surgical treatment. Eur J Cardiothorac Surg 2001;19:589-93.  Back to cited text no. 4
[PUBMED]    
5.
KransdorfMJ. Benign soft-tissue tumors in a large referral population: Distribution of specific diagnoses by age, sex, and location. AJR Am J Roentgenol 1995;164:395-402.  Back to cited text no. 5
    
6.
HuS, ChenY, WangY, ChenKM, SongQ. Clinical and CT manifestation of pleural schwannoma. Acta Radiol 2012;53:1137-41.  Back to cited text no. 6
[PUBMED]    
7.
KinhalVA, RavishankarTH, MelapureAI, JayaprakashaG, Range GowdaBC, Manjunath BC. Pancreatic schwannoma: Report of a case and review of literature. Indian J Surg 2010;72Suppl1:296-8.  Back to cited text no. 7
    
8.
AbbasA, JonesH, KingstonGT, ZurekA. Malignant peripheral nerve sheath tumour presenting as a pneumothorax. Br J Radiol 2011;84:e197-9.  Back to cited text no. 8
[PUBMED]    
9.
GuptaG, ManikerA. Malignant peripheral nerve sheath tumors. Neurosurg Focus 2007;22:E12.  Back to cited text no. 9
[PUBMED]    
10.
HsuPK, HsuHS, LeeHC, HsiehCC, WuYC, WangLS, etal. Management of primary chest wall tumors: 14years' clinical experience. JChin Med Assoc 2006;69:377-82.  Back to cited text no. 10
[PUBMED]    
11.
O'SullivanP, O'DwyerH, FlintJ, MunkPL, MullerN. Soft tissue tumours and mass-like lesions of the chest wall: A pictorial review of CT and MR findings. Br J Radiol 2007;80:574-80.  Back to cited text no. 11
    
12.
EnzingerFM, WeissSW. Benign tumors of the peripheral nerves. In: Soft Tissue Tumors. 3rded. St. Louis: Mosby; 1995. p.821-8.  Back to cited text no. 12
    


    Figures

  [Figure 1]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Introduction
Case Report
Discussion
Conclusion
References
Article Figures

 Article Access Statistics
    Viewed1854    
    Printed34    
    Emailed0    
    PDF Downloaded132    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]