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The comparison of properties of Ti-6Aluminum-4Vanadium porous scaffolds fabricated through low-power selective laser Melting and electron beam melting
Jun Hu1, Yiwei Wang2, Minjie Fan2, Qingqiang Yao3, Pengfei Zheng4
1 Department of Trauma Center, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China
2 Department of Orthopaedic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
3 Department of Orthopaedic Surgery, Nanjing First Hospital; Key Lab of Biomaterial and Additive Manufacturing Research, Institute of Digital Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
4 Department of Orthopaedic Surgery, Children's Hospital of Nanjing Medical University; Department of Orthopaedic Surgery, Nanjing First Hospital; Key Lab of Biomaterial and Additive Manufacturing Research, Institute of Digital Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
Correspondence Address:
Pengfei Zheng
Department of Orthopaedic surgery, Children's Hospital of Nanjing Medical University, 8th South Jiangdong Road, Jianye Distrcit, Nanjing 210008
China
Qingqiang Yao
Department of Orthopaedic Surgery, Nanjing First Hospital, 68th Changle Road, Qinhuai District, Nanjing 210006
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/digm.digm_46_21
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Background and Purpose: Three-dimensional printing (3DP) selective laser melting (SLM) and electron beam melting (EBM) technique can construct porous Ti-6Aluminum-4Vanadium (Ti-6Al-4V) scaffolds with special microstructural and biomechanical properties. However, it is still needed to be tested for bone tissue engineering. Materials and Methods: To investigate the microstructure and surface modification of a porous titanium scaffold, 3DP-SLM technique was used, and the mechanical and biological performance of the scaffolds was compared with that fabricated by EBM technique. Ti-6Al-4V scaffolds were computer-designed and fabricated using low-power SLM (L-SLM). The microstructure morphologies of L-SLM Ti-6Al-4V (L-SLM-Ti) scaffolds were determined and compared with EBM-fabricated Ti-6Al-4V (EBM-Ti) scaffolds. Each scaffold was immersed with marrow clot for 1 h until fully combined with bone mesenchymal stem cells in clots. The biomechanical and cellular response of these two kinds of Ti-6Al-4V scaffolds were compared. Results: The L-SLM-Ti scaffolds showed a microstructure closer to the designed parameters than that of the EBM-Ti scaffolds. The L-SLM-Ti scaffold fibers had a rougher surface than the EBM-Ti scaffolds. Meanwhile, L-SLM-Ti scaffolds had a lower elasticity modulus and lower bearing force than EBM-Ti scaffold. Cell proliferation and the relative expression levels of OPN, COL1, and RUNX2 in L-SLM-Ti scaffolds was apparently higher than in the EBM-Ti scaffolds, with no significant difference found between the percentage of live cells found in L-SLM-Ti and EBM-Ti scaffolds. Conclusion: 3DP-Ti-6Al-4V scaffolds fabricated by L-SLM and designed with rougher surfaces and larger pore sizes may have more reasonable biomechanical properties and increased biological performance than traditional EBM-Ti scaffolds. These L-SLM-Ti scaffolds might be suitable candidates for bone defect repair.
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